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- Dedication
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-
- It started as a way to spend a rainy Saturday afternoon, and it
- ended up profoundly affecting the lives of tens of thousands of
- people.
-
- Howard Benner through TAPCIS brought to life for many of us the
- very idea of an online community. His legacy is a part of our work
- and our play every single day.
-
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-
- Howard Benner died in June of 1990 at the age of 44 due to
- complications of malignant melanoma. Howard's pioneering work has
- made access to CompuServe easy for us. Unfortunately, much
- pioneering work in melanoma treatment remains to be performed.
-
- Malignant melanoma is a highly malignant cancer of the skin. It
- is the ninth most common cancer in the US and is now the most
- common cancer in women between ages 25 and 29. The incidence of
- melanoma has doubled in the past 10 years. In 1989, over 27,000
- new cases of melanoma were diagnosed, and there were 6,000 deaths
- from the disease.
-
- There is a strong causal relationship between excessive exposure
- to sun and melanoma. Many investigators believe that the rise in
- the rate of melanoma is closely related to the desire for a
- perpetual sun tan. Depletion of the ozone layer and the
- consequent reduction in ultra-violet filtration has also been
- implicated in the rising rate of melanoma occurrence. Support for
- the conclusion that excessive tanning is causal in the development
- of melanoma is the site of onset, in men on the back, shoulders,
- or abdomen and in women on the legs, all sites that are only
- occasionally subject to sunlight and thus easily "sun-burned".
-
- According to the American Cancer Society, people who have had 3 or
- more blistering sunburns are at 5 times the risk for developing
- melanoma compared to people who have never been burned. There are
- many today who feel that even gradual tanning is not safe.
-
- Of considerable concern is the feeling that melanoma may remain
- dormant for many years. Thus melanomas initiated 20-30 years ago
- before strong sun-screens were available may first be coming
- apparent now.
-
- Risk factors also include fair complexion, family history, and a
- markedly freckled back or shoulders. The incidence of melanoma
- amongst Caucasians is significantly greater than that in Blacks or
- Orientals.
-
- In its initial stages, melanoma is treatable and curable. There
- is a definite cutoff point between the size and thickness of the
- melanoma lesion and its curability. In its early stage, melanoma
- is treated by surgical excision with almost 100% cure. However,
- beyond a very sharply defined lesion size (thickness > 0.75mm),
- melanoma becomes essentially 100% fatal today.
-
- Today, metastatic (spread) melanoma remains incurable. However, in
- the past few years several new approaches to therapy have shown
- considerable promise. New approaches include developing a vaccine
- which kills melanoma cells. An experimental melanoma vaccine has
- been derived by infecting melanoma cells grown in cell culture
- with a virus and then injecting material from these cells into
- melanoma patients to induce the production of antibodies to the
- viral/melanoma combination. In initial trials of this "vaccine",
- there has been a significant decrease in disease recurrence in
- patients with metastatic melanoma. It is possible that high-risk
- patients may some day be able to receive an anti-melanoma vaccine.
-
- Another promising approach includes the use of interferon and/or
- interleukin -2, biologicals which have shown reasonable success in
- melanoma patients but unfortunately, interleukin-2 is particularly
- toxic. This approach is not specific for melanoma but has been
- also used in patients with renal cell cancer.
-
- A third approach utilizes augmented "killer lymphocytes", which
- patients with melanoma frequently develop. These "killer
- lymphocytes" appear to seek and destroy melanoma cells.
- Alteration of these naturally occurring killer cells using
- recombinant DNA methods may actually increase their ability to
- kill melanoma cells. This technique is quite new and will not be
- available for many years.
-
- Currently, while there are several promising treatments for
- melanoma, prevention remains the most obvious way of combating the
- disease. An understanding of the long term risks of excessive sun
- exposure and taking steps to reduce that exposure is the single
- most effective way of reducing the likelihood of disease.
-
- Everyone should perform a regular self examination looking for
- these danger signs in moles on your skin. Check carefully under
- arms, between toes, back and top of your head, back... everywhere.
- Become familiar with the moles you have, then watch for changes:
-
- ASYMMETRY: One half the mole is unlike the other half.
-
- BORDER IRREGULAR: The mole appears ragged or scalloped.
-
- COLOR VARIED: The mole changes color from one area to another.
- Shades of brown and tan may contain red, white, and blue.
-
- DIAMETER: Moles larger than 1/4 inch (the width of a pencil
- eraser.
-
- Not all moles that fit into one of these categories is cancer, but
- they should be brought to the attention of your physician.
- Malignant melanoma often signals its presence by a change in an
- ordinary mole. A mole that grows darker, wider, thicker, becomes
- irregular, or starts to itch, hurt, or bleed should get immediate
- attention. If a melanoma is found early and removed, the disease
- can be completely cured. Do NOT put it off.
-
- Support Group, Inc., has made arrangements with the Eastern
- Cooperative Oncology Group (ECOG) to establish a research fund in
- Howard's name. The money in this fund will be devoted to
- supporting research aimed toward finding a cure for malignant
- melanoma using biological agents. An initial donation of $5,000
- has been made, and Support Group's share of TAPCIS Forum revenues
- will be donated to this cause.
-
- Anyone interested in making a donation in Howard's name is
- encouraged to make a check out to ECOG and send it to Support
- Group, Inc., P.O. Box 130, McHenry, MD 21541. We will be sending
- details on each contributor to Howard's family, so feel free to
- include a note if you wish.
-
- If you would like more information about the ECOG, please feel
- free to drop a mail or forum message to Richard Wilkes, President,
- Support Group, Inc., 76701,23. Dr. John Wexler was a great source
- of information for Howard during his illness, and John has also
- offered to help answer questions you may have. John can be reached
- at user ID 71360,3070.